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Radioiodine Therapy Induces Dose-Dependent In Vivo Oxidation Injury: Evidence by Increased Isoprostane 8-Epi-PGF2{alpha}

Roswitha M. Wolfram, MD1, Alexandra C. Budinsky, MS2, Barbara Palumbo, MD3, Renato Palumbo, MD3 and Helmut Sinzinger, MD4,5

1 Department of Angiology, University of Vienna, Vienna, Austria
2 Clinical Division of Oncology, Department of Internal Medicine I, University of Vienna, Vienna, Austria
3 Institute of Nuclear Medicine, University of Perugia, Perugia, Italy
4 Department of Nuclear Medicine, University of Vienna, Vienna, Austria
5 Wilhelm Auerswald Atherosclerosis Research Group (ASF) Vienna, Vienna, Austria



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  		FIGURE 1. Kinetic of plasma 8-epi-PGF2{alpha} after radioiodine therapy. Dose-dependent increase in 8-epi-PGF2{alpha} is seen, with maximum at days 3 and 4 after therapy. Decline seems also to be dose dependent. D = day; W = week.

 


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  		FIGURE 2. Kinetic of serum 8-epi-PGF2{alpha} after radioiodine therapy. Dose-dependent increase in 8-epi-PGF2{alpha} is seen, with maximum at days 3 and 4 after therapy. Decline seems also to be dose dependent. D = day; W = week.

 


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  		FIGURE 3. Kinetic of urinary 8-epi-PGF2{alpha} after radioiodine therapy. Dose-dependent increase in 8-epi-PGF2{alpha} is seen, with maximum at days 3 and 4 after therapy. Decline seems also to be dose dependent. D = day; W = week.

 




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