18F-FDG PET in Localization of Frontal Lobe Epilepsy: Comparison of Visual and SPM Analysis
Yu Kyeong Kim, MD1,
Dong Soo Lee, MD1,
Sang Kun Lee, MD2,
Chun Kee Chung, MD3,
June-Key Chung, MD1 and
Myung Chul Lee, MD1
1 Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Korea
2 Department of Neurology, College of Medicine, Seoul National University, Seoul, Korea
3 Department of Neurosurgery, College of Medicine, Seoul National University, Seoul, Korea
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FIGURE 1. Sensitivities of MRI, 18F-FDG PET by visual assessment, and SPM analysis.
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FIGURE 2. A 16-y-old boy with left FLE (Table 1; patient 2). From left to right, brain MRI findings were normal, 18F-FDG PET showed decreased metabolism in left frontal lobe, and SPM (P < 0.05, corrected) gave same finding. After left frontal lobectomy, he was seizure free during follow-up of 15 mo.
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FIGURE 3. Example of SPM analysis with varying threshold (Table 1; patient 16). According to cutoff value of voxel height, SPM analysis became less sensitive when stricter criterion was applied.
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FIGURE 4. A 24-y-old woman with intractable partial seizure (Table 1; patient 9). Her MRI findings were normal. (A) In 18F-FDG PET scan, widely decreased metabolism in left hemisphere was detected visually. (B) SPM showed localized decrease in metabolism in left inferior frontal lobe (P < 0.005, uncorrected). After left inferior frontal lobectomy, she was seizure free.
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Copyright © 2002 by the Society of Nuclear Medicine.
