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Comparison of PET with Radioactive Microspheres to Assess Pulmonary Blood Flow

¹ Équipe d’Accueil 1896, Université Claude Bernard Lyon I, Lyon, France
² Centre d’Etudes et de Recherche Médicales par Tomographie d’Emission de Positrons, Hôpital Neuro-Cardiologique, Lyon, France
³ Service de Réanimation Médicale et Assistance Respiratoire, Lyon, France

View larger version (60K): [in a new window]   FIGURE 1. Lung PET images of 1 pig. (A) Transmission scan used to identify lung ROIs. (B) Image obtained 6 s after injection of 2 mCi (74 MBq) H215O and used to draw ROI inside right ventricle. (C) Image obtained 38 s after injection of 2 mCi (74 MBq) H215O. (D) TAC curves of right ventricle and lung obtained from preceding drawn ROIs.

View larger version (49K): [in a new window]   FIGURE 2. Method of lung sectioning. (A) First, most peripheral regions of upper, lower, external, and internal parts of each lung were excised over 1 cm (). Each lung was then sectioned into transverse slices (9 for right lung and 6 for left lung). (B) Then, each of these sections was divided into 2 coronal planes. (C) Last, each coronal slice was divided into 3 sagittal sections.

View larger version (19K): [in a new window]   FIGURE 3. Using Equation 1, adequacy of fit of lung activity in 1 representative pig.

View larger version (27K): [in a new window]   FIGURE 4. Relationships between PET-PBF and MS-PBF. (A) Relationship between PET-PBF and MS-PBF in the 5 lung regions. (B) Assessment of bias in PBF between PET and MS techniques. Each symbol is value of PBF in 1 lung region in a given experimental condition in 1 animal. Corresponding regression equations are also shown. Dotted line is regression line obtained over all experimental points. Dashed line is line of identity.

View larger version (17K): [in a new window]   FIGURE 5. Input function assessment. (A and B) Plots of activities in right ventricle (solid lines) and pulmonary artery (dotted lines) before (A) and after (B) correction for time shift in pig 4 during baseline condition. (C) Individual (•) and mean (±SD) values () of relative errors of input function as function of time of PET image. Relative error of input function was computed as ratio of difference in right ventricle and pulmonary artery activities to mean of right ventricle and pulmonary artery activities. (D) Relationship between noninvasive and invasive input functions. Values of input function are expressed as integral of time-activity curves over first 60 s after water injection.

View larger version (27K): [in a new window]   FIGURE 6. Simulations of PBF. Fitted relationships between bias in PBF and tracer transit delay for pulmonary artery and lung tissue (d in Eq. 1) at different fixed values of PBF. Bias was assessed as relative error in PBF and computed from ratio of difference between simulated and true values of PBF to true value of PBF.