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Reducing Loss of Image Quality Because of the Attenuation Artifact in Uncorrected PET Whole-Body Images

¹ Nuclear Medicine, Katholieke Universiteit Leuven, Leuven, Belgium

View larger version (36K): [in a new window]   FIGURE 1. Radioactive ring in uniform attenuating disk. Dashed circle represents boundary of uniform attenuation. Bold circle represents radioactive ring. Because of attenuation, projection through center (thick arrow) contains fewer counts than do 2 tangential projections (2 thin arrows), although same activity is projected.

View larger version (18K): [in a new window]   FIGURE 2. (A) Original activity distribution, with dotted circle indicating attenuating disk. (B) Reconstruction without attenuation correction from attenuated projections. (C) Profile through center of reconstruction image.

View larger version (67K): [in a new window]   FIGURE 3. Tumor detection simulation experiment. (A) True image and regions (ROIs) used to compute object and background tracer uptake. (B) FBP reconstructions with (ATTCOR) and without (NO COR) attenuation correction. (C) MLEM with and without attenuation correction and NEG-ML without attenuation correction.

View larger version (111K): [in a new window]   FIGURE 4. PET study of 10 bed positions, 4 mm per bed position, on ECAT 931 (CTI, Knoxville, TN/Siemens Medical Systems, Inc., Hoffman Estates, IL). (A) FBP reconstruction. (B) MLEM reconstruction. (C) NEG-ML reconstruction.

View larger version (116K): [in a new window]   FIGURE 5. PET study of 7 bed positions, 5 mm per bed position, on ECAT HR+ (CTI, Knoxville, TN/Siemens Medical Systems, Inc., Hoffman Estates, IL). (A) MLEM reconstruction. (B) NEG-ML reconstruction. Four consecutive coronal slices are shown, from anterior toward posterior, and indicate normal findings.

View larger version (17K): [in a new window]   FIGURE 6. Radioactive ring in uniform attenuating disk.