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Prognostic Significance of ¹⁸F-FDG and ^99mTc-Methylene Diphosphonate Uptake in Primary Osteosarcoma

¹ Department of Nuclear Medicine, Münster University Hospital, Münster, Germany
² Department of Pediatric Hematology and Oncology, Münster University Hospital, Münster, Germany

View larger version (16K): [in a new window]   FIGURE 1. Disease outcome for whole patient group as determined by Kaplan-Meier analyses using overall survival (A) and event-free survival (B). Tick marks indicate individual follow-up period.

View larger version (37K): [in a new window]   FIGURE 2. Disease outcome for 99mTc-MDP T/NTmax (overall survival [A] and event-free survival [B]) and 18F-FDG T/NTmax (overall survival [C] and event-free survival [D]) as determined by Kaplan-Meier analyses. Median levels were used as cutoff values. Tick marks indicate individual follow-up period.

View larger version (18K): [in a new window]   FIGURE 3. Relationship between various 18F-FDG T/NTmax cutoff values and their discriminative value for both overall survival (A) and event-free survival (B) as assessed by log-rank test. Broad range of 18F-FDG T/NTmax ratios gave significant log-rank probability values (P < 0.05).