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Metabolic Fate of 18F-FDG in Mice Bearing Either SCCVII Squamous Cell Carcinoma or C3H Mammary Carcinoma

Katrin Kaarstad, MD1, Dirk Bender, PhD1, Lise Bentzen, MD2, Ole Lajord Munk, MSc1 and Susanne Keiding, DSc1,3

1 PET Center, Aarhus University Hospital, Aarhus, Denmark
2 Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark
3 Department of Medicine V, Aarhus University Hospital, Aarhus, Denmark



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  		FIGURE 1. Analytic radio-HPLC of mixture of 18F-FDG, 18F-FDG-6-P, 18F-FD-PG1, and 18F-FDG-1,6-P2. Compounds were prepared individually by in vitro enzymatic reactions and mixed afterward (SphereClone [Phenomenex, Torrance, CA] 5-µm SAX 250 x 4.6 mm column; 20 mmol/L potassium phosphate buffer; pH 7.2; flow rate, 0.8 mL/min).

 


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  		FIGURE 2. Typical radio-HPLC results for analysis of 18F-FDG in squamous tumor tissue extracts 80 min after 18F-FDG injection.

 


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  		FIGURE 3. Radio-HPLC-determined time course of percentage tissue content of 18F-FDG ({circ}), 18F-FDG-6-P({blacktriangleup}), 18F-FD-6-PG1 (+18F-FD-6-PGL) ({blacktriangledown}), and 18F-FDG-1,6-P2 (•) in SCCVII carcinoma grown on mice.

 


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  		FIGURE 4. Radio-HPLC-determined time course of percentage tissue content of 18F-FDG ({circ}), 18F-FDG-6-P({blacktriangleup}), and 18F-FD-PG1(+18F-FD-6-PGL) + 18F-FDG-1,6-P2 ({blacktriangledown}) in C3H carcinoma grown on mice.

 


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  		FIGURE 5. Time course of total radioactivity concentrations (18F-FDG + 18F-metabolites) in SCCVII carcinoma ({circ}), C3H carcinoma (•), and liver tissue from respective mice ({square}, {blacksquare}). Concentrations are normalized for tissue protein concentrations and individual 18F-FDG doses.

 


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  		FIGURE 6. Metabolic pathways for 18F-FDG.

 




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