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99mTc-HMPAO–Labeled Autologous Versus Heterologous Leukocytes for Imaging Infection

Stefan Gratz, MD1,2, Huub J.J.M. Rennen, MSc1, Otto C. Boerman, PhD1, Wim J.G. Oyen, MD1, Peter Mast3, Thomas M. Behr, MD2 and Frans H.M. Corstens, MD1

1 Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands
2 Department of Nuclear Medicine, Philipps University Marburg, Marburg, Germany
3 Department of Hematology, University Medical Center Nijmegen, Nijmegen, The Netherlands



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  		FIGURE 1. Scintigrams of rabbits with Escherichia coli infection in left calf muscle imaged at (from left to right) 2 min and at 1, 2, and 4 h after injection of 99mTc-HMPAO autologous purified granulocytes (A) and 99mTc-HMPAO-purified granulocytes derived from infected (B) and noninfected (C) donor rabbits.

 


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  		FIGURE 2. Quantitative analysis (mean ± SD) of scintigrams of rabbits shows clearance from lungs (top set of 3 lines), liver (middle set of 3 lines), and spleen (bottom set of 3 lines). Top line of each set is data for injection of 99mTc-HMPAO autologous granulocytes, middle line of each set is data for injection of 99mTc-HMPAO heterologous granulocytes from infected donors, and bottom line of each set is data for injection of 99mTc-HMPAO heterologous granulocytes from noninfected donors. Whole-body activity measured at 2 min after injection was set at 100%; error bars represent SD.

 


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  		FIGURE 3. Abscess uptake (%ID) of 99mTc-HMPAO autologous granulocytes and of 99mTc-HMPAO heterologous granulocytes from infected and noninfected donors at 2 min and at 1, 2, and 4 h after injection

 


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  		FIGURE 4. Abscess-to-background (noninfected contralateral muscle) ratio (T/B ratio) at 2 min and at 1, 2, and 4 h after injection of 99mTc-HMPAO autologous granulocytes and of 99mTc-HMPAO heterologous granulocytes from infected and noninfected donors.

 




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