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High-Resolution Scintimammography: A Pilot Study

¹ Breast Imaging and Intervention Center, George Washington University Medical Center, Washington, DC
² Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Institutions, Baltimore, Maryland
³ Thomas Jefferson National Accelerator Facility, Newport News, Virginia
⁴ Department of Oncology, Johns Hopkins Institutions, Baltimore, Maryland

View larger version (109K): [in a new window]   FIGURE 1. Imaging using high-resolution breast-specific gamma camera in mediolateral projection (A), comparable with projection obtained with mammography, and craniocaudal projection (B).

View larger version (117K): [in a new window]   FIGURE 2. Imaging using -isolation shield in craniocaudal (A) and mediolateral oblique (B) projections to reduce image contamination from extramammary radiotracer uptake and to apply mild compression.

View larger version (22K): [in a new window]   FIGURE 3. Comparative resolution of traditional gamma camera using high-resolution (HR), high-efficiency collimators and breast-specific gamma camera. y-axis = resolution (mm).

View larger version (54K): [in a new window]   FIGURE 4. Detection of unsuspected cancer with high-resolution breast-specific gamma camera in 33-y-old woman 2 y after lumpectomy and radiation therapy for infiltrating ductal carcinoma of right breast. Area of architectural distortion appeared in right breast, for which scintimammography was performed. Mediolateral oblique (A) and craniocaudal (B) mammograms of left breast showed normal findings. Scintimammogram with high-resolution breast-specific gamma camera showed normal findings in right breast. However, images of left breast (C) showed focal area of radiotracer uptake in upper (arrow) outer (arrowhead) quadrant of left breast. (D) Images with conventional gamma camera showed possible minimal radiotracer uptake in superior left breast. Biopsy showed 4-mm infiltrating ductal carcinoma.