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A Bayesian Regression Model for Plasma Clearance

¹ University of Alabama Hospital and VA Medical Center, Birmingham, Alabama
² Emory University, Atlanta, Georgia

View larger version (15K): [in a new window]   FIGURE 1. Correlation of Bayesian 1- and 2-sample methods and Christensen—Groth 1-sample method (5) with multisample reference method. Sampling was at approximately 3 h for 1-sample methods and at 1 and 3 h for 2-sample method.

View larger version (11K): [in a new window]   FIGURE 2. GFR vs. effective volume (Veff) of distribution at 3 h after injection, for adult of average size, calculated from Bayesian parameter estimates and from Christensen—Groth formula (5).

View larger version (13K): [in a new window]   FIGURE 3. GFR vs. effective volume (Veff) of distribution at 2 h after injection, for 1-y-old child of average size, from Bayesian parameter estimates for 99mTc-DTPA and from 2 pediatric formulas for 15Cr-EDTA: Groth—Aasted (10) and Ham—Piepsz (14).