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201Tl and 99mTc-MIBI Retention in an Isolated Heart Model of Low-Flow Ischemia and Stunning: Evidence of Negligible Impact of Myocyte Metabolism on Tracer Kinetics

Adey Ayalew, MSc1, Pierre-Yves Marie, MD1, Patrick Menu, PhD2, Paul-Michel Mertes, MD3, Sandra Audonnet, MSc1, Valérie Jouan, MSc2, Pierre Olivier, MD1, Gilles Karcher, MD1, Dan Ungureanu-Longrois, MD4 and Alain Bertrand, MD1

1 Department of Nuclear Medicine, UPRES EA 2403, CHU-Nancy, France
2 Laboratory of Hematology and Physiology, Faculty of Pharmacy, University Henri Poincaré, Nancy, France
3 Department of Cardiology, UPRES EA 2403, CHU-Nancy, France
4 Department of Anesthesia, UPRES EA 2403, CHU-Nancy, France



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  		FIGURE 1. Variations in systolic contraction pressure (A) and coronary flow rates (B) between onset and end of experiments conducted in normoxia ({circ}; n = 16), low-flow ischemia (•; n = 15), and stunning (; n = 15).

 


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  		FIGURE 2. Comparison of activity in interstitial fluid for 201Tl (A) and MIBI (B) during experiments conducted in normoxia ({square}; n = 16), low-flow ischemia ({blacksquare}; n = 15), and stunning (; n = 15). Activities expressed as a fraction of total injected activity per milliliter of interstitial fluid for each of 4 consecutive 10-min periods following myocardial extraction of tracer. *P < 0.05.

 


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  		FIGURE 3. Comparison of tracer concentration ratios between interstitial (Ci [g-1]) and cellular (Cc [g-1]) spaces for 201Tl (A) and MIBI (B) during experiments conducted in normoxia ({square}; n = 16), low-flow ischemia ({blacksquare}; n = 15), and stunning (; n = 15). Activity ratios determined for each of 4 consecutive 10-min periods following myocardial extraction of tracer. *P < 0.05.

 


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  		FIGURE 4. Comparison of average tracer myocardial retention fractions for 201Tl (A) and MIBI (B) during experiments conducted in normoxia ({square}; n = 16), low-flow ischemia ({blacksquare}; n = 15), and stunning (; n = 15). Fractions calculated for each of 4 consecutive 10-min periods following myocardial extraction of tracer. *P < 0.05.

 




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