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Effect of Endomyocardial Laser Channels on Regional Innervation Shown with ¹²⁵I-MIBG and Autoradiography

¹ Rhode Island Hospital, Brown University, Providence, Rhode Island
² University of California at San Francisco, San Francisco, California

View larger version (39K): [in a new window]   FIGURE 1. Display of 3-dimensional unipolar voltage maps in shallow left anterior oblique projection acquired using NOGA catheter mapping system. (A) Map was done at baseline before laser therapy and shows normal unipolar voltage. (B) Map was done during laser therapy. White points on left ventricular map represent mapping points, and orange dots represent sites of laser administration to endocardial surface of anteroapical wall. Color bars represent 5 (orange) to 15 (blue/purple) mV. White disk represents animal’s head and is placed for orientation.

View larger version (40K): [in a new window]   FIGURE 2. Hematoxylin–eosin staining (A) and autoradiograms (B) from 1 experiment. Each tissue section was mounted on a slide. Sections were selected to include sites of laser treatment. (A and B) Ten sections displayed in 2 rows. (A) Regions of laser channels are marked by blue circles. (B) Phosphor screen captured image of perfusion tracer (99mTc-sestamibi) is displayed in gray scale and superimposed are results of 2 subtraction processes. Red pixels represent relatively higher MIBG than MIBI and green pixels represent relatively lower MIBG than MIBI when compared with remaining myocardium (gray). Yellow circles correspond to locations of laser holes identified from hematoxylin–eosin sections. Only 1 laser site with confluent green pixels showed reduced MIBG (second section from right in second row).