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Effects of Carvedilol on Cardiac Function and Cardiac Adrenergic Neuronal Damage in Rats with Dilated Cardiomyopathy

Kenichi Watanabe, MD1, Toshihiro Takahashi, PhD2, Mikio Nakazawa, PhD3, Mir I. I. Wahed, PhD1, Koichi Fuse, MD4, Naohito Tanabe, MD4, Makoto Kodama, MD4, Yoshifusa Aizawa, MD4, Hiroki Ashino, PhD5 and Shusaku Tazawa, PhD5

1 Department of Clinical Pharmacology, Niigata College of Pharmacy, Niigata, Japan
2 Radioisotope Center, Niigata University School of Medicine, Niigata, Japan
3 Department of Medical Technology, School of Health Sciences, Niigata University School of Medicine, Niigata, Japan
4 First Department of Medicine, Niigata University School of Medicine, Niigata, Japan
5 Daiichi Radioisotope Laboratories, Ltd., Chiba, Japan



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  		FIGURE 1. Effects of carvedilol on hemodynamic parameters. Although central venous pressure, mean blood pressure, peak left ventricular pressure, and ±dP/dt did not differ between groups V and C, left ventricular end-diastolic pressure was significantly lower in group C than in group V. BP = blood pressure; CVP = central venous pressure; LVP = left ventricular pressure; max = maximum; min = minimum.

 


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  		FIGURE 2. Effects of carvedilol on myocardial fibrosis, heart size, and myocardial uptake of 125I-MIBG. Figures are representative of each group. Blue (azan staining) indicates fibrosis determined by histology. Red and blue indicate high and low myocardial uptake of MIBG determined by scintigraphy. MIBG uptake in rats with dilated cardiomyopathy was decreased not only in area of fibrosis but also in intact area. Top shows MIBG scintigram at 10 min after tracer injection. Bottom shows MIBG scintigram at 240 min after tracer injection.

 




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