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Relative Uptake, Metabolism, and ß-Receptor Binding of (1R,2S)-4-¹⁸F-Fluorometaraminol and ¹²³I-MIBG in Normotensive and Spontaneously Hypertensive Rats

¹ Institut für Nuklearchemie Forschungszentrum Jülich, Jülich, Germany

View larger version (18K): [in a new window]   FIGURE 1. Pattern of regions of interest to analyze cardiac distribution of 4-18F-FM and 123I-MIBG. LA = left atrium; RA = right atrium; RVB = right ventricle basal; RVA = right ventricle apical (reference region); LVB = left ventricle basal; LVA = left ventricle apical.

View larger version (16K): [in a new window]   FIGURE 2. Relative uptake and metabolites of 4-18F-FM in SHR and WKY tissue samples. Total uptake in tissue of organs and in blood is given as percentage of cardiac activity (mean ± SEM). Black columns, SHR (n = 3); white columns, WKY (n = 3). Hatched areas (mean ± SEM) show contribution of metabolites to total uptake. Asterisk indicates significant difference between SHR and WKY animals.

View larger version (14K): [in a new window]   FIGURE 3. Relative uptake and metabolites of 123I-MIBG in SHR and WKY tissue samples. Total uptake in tissue of organs and in blood is given as percentage of cardiac activity (mean ± SEM). Black columns, SHR (n = 6); white columns, WKY (n = 6). Hatched areas (mean ± SEM) show contribution of metabolites to total uptake. Asterisks indicate significant difference between SHR and WKY animals.

View larger version (15K): [in a new window]   FIGURE 4. Effect of S-(-)-propranolol, MIBG, and 4-FM on binding of 123I-ICYP in cardiac tissue of SHR and WKY animals. Inhibitory efficiency of ß-receptor binding of 4-FM is compared with that of MIBG and propranolol (125I-ICYP, 1.5 pmol/L; inhibitors, 10 µmol/L each). Black columns, SHR (n = 6–8); white columns, WKY (n = 6–8). Data are expressed as mean ± SEM. Asterisks indicate significant differences to total binding.

View larger version (17K): [in a new window]   FIGURE 5. Effect of S-(-)-propranolol, MIBG, and 4-FM on binding of 125I-ICYP in spleen of SHR and WKY animals. Inhibitory efficiency of ß-receptor binding of 4-FM is compared with that of MIBG and propranolol (125I-ICYP, 1.5 pmol/L; inhibitors, 10 µmol/L each). Black columns, SHR (n = 11); white columns, WKY (n = 11). Data are expressed as mean ± SEM. Asterisks indicate significant differences to total binding.