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Quantification of Lymphatic Function for Investigation of Lymphedema: Depot Clearance and Rate of Appearance of Soluble Macromolecules in Blood

¹ Cambridge Breast Unit, Addenbrooke’s Hospital, Cambridge, United Kingdom
² Department of Nuclear Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom
³ Department of Medicine, St. George’s Hospital Medical School and The Royal Marsden National Health Service Trust, London, United Kingdom

View larger version (25K): [in a new window]   FIGURE 1. Pooled depot clearance data (plotted as mean natural logarithm [ln] of remaining activity) with trend lines from which rate removal constant k (% . min-1) is calculated for HSA (n = 6) (A) and HIgG (n = 12) (B) with error bars showing 1 SD.

View larger version (18K): [in a new window]   FIGURE 2. Pooled venous activity profiles for HSA (n = 6) (A) and HIgG (n = 12) (B). %/l = percentage of administered activity per liter of blood.

View larger version (18K): [in a new window]   FIGURE 3. Rate removal constant, k (in % . min-1), plotted against total venous activity at 3 h (% injected activity) for HSA (A and B) and HIgG (C and D). • = 111In in healthy volunteers; = 111In in preoperative patients; = 99mTc in healthy volunteers; = 99mTc in preoperative patients.