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Longitudinal Evaluation of Both Morphologic and Functional Changes in the Same Individuals with Alzheimer’s Disease

¹ Department of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan
² Department of Radiology, University of Washington Medical Center, Seattle, Washington
³ Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan
⁴ Department of Neuropsychiatry, Tsukuba University, Ibaraki, Japan
⁵ Department of Geriatric Medicine, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan

View larger version (99K): [in a new window]   FIGURE 1. SPM99 corrected for multiple comparisons (P = 0.05). Images show significantly lower (P = 0.001) gray matter volume in AD patients, in comparison with that in healthy volunteers, at baseline (A) and at 1-y (B) and 2-y (C) follow-up. Significant decrease is shown as colored areas superimposed on transaxial slices of standard MR images.

View larger version (102K): [in a new window]   FIGURE 2. SPM99 corrected for multiple comparisons (P = 0.05). Images show significantly lower (P = 0.001) adjusted rCBF in relative flow distribution (normalization of global cerebral blood flow for each subject to 50 mL/100 g/min with proportional scaling) in AD patients, in comparison with that in healthy volunteers, at baseline (A) and at 1-y (B) and 2-y (C) follow-up. Significant decrease is shown as colored areas superimposed on transaxial slices of standard MR images.

View larger version (65K): [in a new window]   FIGURE 3. SPM99 corrected for multiple comparisons (P = 0.05). Dual-color display of surface-rendered standard MR images from 8 viewpoints shows significantly lower (P = 0.001) gray matter volume (red) and rCBF (green) in AD patients, in comparison with those in healthy volunteers. Areas of overlap are indicated by yellow.