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Evaluation of 99mTc-Ciprofloxacin Scintigraphy in a Rabbit Model of Staphylococcus aureus Prosthetic Joint Infection

Laure Sarda, MD1, Azzam Saleh-Mghir, PhD2, Can Peker, MD3, Alain Meulemans, PhD3, Anne-Claude Crémieux, MD, PhD2 and Dominique Le Guludec, MD, PhD3

1 Service Hospitalier Frédéric Joliot, CEA, Orsay, France
2 INSERM EMI-U 99-33, Paris, France
3 Service de Médecine Nucléaire, Hôpital Bichat, Paris, France



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  		FIGURE 1. 99mTc-ciprofloxacin scintigraphy (images obtained 4 h after injection). (A) Infected rabbit: increasing and expanding 99mTc-ciprofloxacin uptake in right infected prosthetic knee (a) 5 d, (b) 12 d, and (c) 19 d after surgery. (B) Uninfected rabbit: significant, increasing 99mTc-ciprofloxacin uptake in right uninfected prosthetic knee (a) 5 d, (b) 12 d, and (c) 19 d after surgery.

 


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  		FIGURE 2. Autoradiography of knee in infected rabbit. (A) Normal (nonoperated) knee: (a) epiphysial disk cartilage, (b) articular cartilage. (B) Infected prosthetic knee: (c) muscle, (d) articular cartilage, (e) tibial prosthesis, (f) tibial bone. (C) Pus.

 


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  		FIGURE 3. Operated-to-normal-knee activity ratios (ONKR) in G1 (infected) and G2 (uninfected) rabbits according to time after knee arthroplasty.

 


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  		FIGURE 4. 99mTc-ciprofloxacin images of uninfected rabbit (A) 1 h, (B) 4 h, and (C) 24 h after 99mTc-ciprofloxacin injection. No decrease in 99mTc-ciprofloxacin uptake is seen in left prosthetic uninfected knee on 24-h images.

 


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  		FIGURE 5. Mean operated-to-normal-knee activity ratios (ONKR) in G1 (infected) and G2 (uninfected) rabbits according to time after injection of 99mTc-ciprofloxacin (regardless of time after surgery).

 




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