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Labeling of Mixed Leukocytes with ^99mTc-HMPAO Causes Severe Chromosomal Aberrations in Lymphocytes

lknur Ak, MD¹, Erkan Vardereli, MD¹, Beyhan Durak, PhD², Zafer Gülba, MD³, Nurettin Basaran, MD², Marcel P.M. Stokkel, PhD⁴ and Ernest K.J. Pauwels, PhD⁴

¹ Department of Nuclear Medicine, Osmangazi University, Eskiehir, Turkey
² Department of Medical Genetics, Osmangazi University, Eskiehir, Turkey
³ Department of Hematology, Osmangazi University, Eskiehir, Turkey
⁴ Department of Radiology, Division of Nuclear Medicine, Leiden University Medical Center, Leiden, The Netherlands

View larger version (87K): [in a new window]   FIGURE 1. Chromosomes of labeled lymphocyte with multiple aberrations. a = chromosome fragments; b = fivecentric chromosome; c = tricentric chromosome; d = chromatid break; e = acentric fragment; f = dicentric chromosome.

View larger version (33K): [in a new window]   FIGURE 2. Metaphase with multiple aberrations. a = chromosome fragments; b = chromatid break; c = acentric fragment; d = fourcentric chromosome; e = dicentric chromosome; f = chromosome break.