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Uptake of ²⁰¹Tl into Primary Cell Cultures from Human Thyroid Tissue Is Multiplied by TSH

¹ Nuklearmedizinische Klinik mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
² Institut für Medizininformatik, Biometrie und Epidemiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
³ Pathologisches Institut, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⁴ Chirurgische Klinik mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

View larger version (28K): [in a new window]   FIGURE 1. Liberation of Tg into culture media as function of time. Accumulation of Tg is markedly enhanced after stimulation by TSH. Curves are representative for primary cultures from human thyroid tissues. Dotted line marks amount of Tg measured in lysate of 1 million cells at time of inoculation. This culture was not included in set of cultures investigated for uptake of 201Tl.

View larger version (21K): [in a new window]   FIGURE 2. Effect of TSH on differentiated functions of human thyrocytes. Release of Tg by primary cultures is enhanced in presence of 10 IU/L bovine TSH. Error bars indicate SDs of average values.

View larger version (22K): [in a new window]   FIGURE 3. Effect of TSH on differentiated functions of human thyrocytes. Uptake of 201Tl by primary cultures is enhanced in presence of 10 IU/L bovine TSH. Error bars indicate SDs of average values.

View larger version (28K): [in a new window]   FIGURE 4. Correlation of 201Tl uptake (%/million cells) with release of Tg (ng/h/million cells). Linear regressions for logarithmically transformed parameters illustrate inverse relationships between parameters in cultures grown in absence of TSH () and in cultures stimulated by TSH (). Error bars indicate SDs of average values.