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Rat Studies Comparing ¹¹C-FMAU, ¹⁸F-FLT, and ⁷⁶Br-BFU as Proliferation Markers

¹ PET Center, Uppsala University Hospital, Uppsala, Sweden
² Department of Pharmaceutics, Uppsala University, Uppsala, Sweden
³ Department of Organic Chemistry, Institute of Chemistry, Uppsala University, Uppsala, Sweden
⁴ Hamamatsu Photonics, Shizuoka, Japan

View larger version (10K): [in a new window]   FIGURE 1. Structures of 11C-FMAU, 18F-FLT, and 76Br-BFU.

View larger version (50K): [in a new window]   FIGURE 2. (A) Uptake of 11C-FMAU, expressed as SUV (mean ± SD) in rat organs. Animals were killed after 5, 20, 40, 60, or 80 min. Different animals were administered cimetidine together with 11C-FMAU or hydroxyurea 30 min before administration of radioactivity. (B) Uptake of 11C-FMAU, expressed as ratio to blood radioactivity concentration (mean ± SD) in rat organs. Animals were killed after 5, 20, 40, 60, or 80 min. Different animals were administered cimetidine with 11C-FMAU or hydroxyurea 30 min before administration of radioactivity.

View larger version (51K): [in a new window]   FIGURE 3. Fraction of 11C-FMAU radioactivity, expressed as percentage of total tissue radioactivity (mean ± SD), recovered in DNA fraction in rat organs. Different animals were administered cimetidine with 11C-FMAU.

View larger version (26K): [in a new window]   FIGURE 4. Uptake of 18F-FLT, expressed as SUV (mean ± SD) in rat organs. Animals were killed after 80 min or 2 or 4 h. Different animals were administered cimetidine with 18F-FLT or hydroxyurea 30 min before administration of radioactivity.

View larger version (36K): [in a new window]   FIGURE 5. (A) Uptake of 76Br-BFU, expressed as SUV (mean ± SD), in rat organs. Animals were killed after 5, 20, 40, 60, or 80 min. Different animals were administered cimetidine with 76Br-BFU and were killed after 5, 20, 40, 60, or 80 min and 2, 4, 6, or 24 h. (B) Uptake of 76Br-BFU, expressed as ratio to blood radioactivity concentration (mean ± SD) in rat organs. Animals were killed after 5, 20, 40, 60, or 80 min. Different animals were administered cimetidine with 76Br-BFU and were sacrificed after 5, 20, 40, 60, or 80 min and 2, 4, 6, or 24 h.

View larger version (49K): [in a new window]   FIGURE 6. Fraction of 76Br-BFU radioactivity, expressed as percentage of total tissue radioactivity (mean ± SD), recovered in DNA fraction in rat organs. Different animals were administered cimetidine with 76Br-BFU.