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18F-Fluoroerythronitroimidazole Radiation Dosimetry in Cancer Studies

Tuula Tolvanen, MSc1, Kaisa Lehtiö, MD1, Jarmo Kulmala, PhD2, Vesa Oikonen, MSc1, Olli Eskola, MSc3, Jörgen Bergman, MSc3 and Heikki Minn, MD1

1 Turku PET Centre, Turku University Central Hospital, Turku, Finland
2 Department of Oncology and Radiotherapy, Turku University Central Hospital, Turku, Finland
3 Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, Turku, Finland



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  		FIGURE 1. Dynamic imaging protocols used for 18F-FETNIM PET dosimetric study. Protocol 1 was used specifically to measure source organ uptake in thorax and abdomen. Protocols 2 and 3 were used in head and neck cancer patients. Frame rates varied in 3 protocols and are explained in text. Tr = transmission scan.

 


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  		FIGURE 2. Activity of 18F-FETNIM in 4 source organs shows clearly higher activity than rest of body: blood, spleen, liver, and kidneys. Solid line is mean curve of individual values. Activity has been normalized to 1-MBq injected dose and 70-kg body weight. Similar shape in curves for blood, liver, and spleen indicates that blood activity has major impact on dose of 2 parenchymal organs.

 


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  		FIGURE 3. Activity of 18F-FETNIM in source organs shows relatively low activity: muscle, brain, bone marrow, and lung. Solid line is mean curve of individual values. Activity has been normalized to 1-MBq injected dose and 70-kg body weight.

 


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  		FIGURE 4. 18F-FETNIM urine activity. Fitted curve is based on 28 samples from 27 patients. Note high percentage of total injected activity excreted in bladder for subjects holding urine. ID = injected dose.

 




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