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Effects of Methylphenidate Discontinuation on Cerebral Blood Flow in Prepubescent Boys with Attention Deficit Hyperactivity Disorder

¹ Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
² Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
³ The Community/Academia Coalition, Mountain View, California
⁴ Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts
⁵ Division of Nuclear Medicine, Stanford University School of Medicine, Palo Alto, California

View larger version (46K): [in a new window]   FIGURE 1. ADHD group subtraction image, on vs. off MPH. Superior and sagittal projections, over standard template, of statistical parametric (t) maps of distribution of differences between on-MPH and off-MPH conditions. Higher rCBF on MPH is seen in bilateral precentral gyri and ACC (Table 2) at t range of 3.4–6.0. P < 0.05, corrected for multiple comparisons. LT = left.