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The Mean Transit Time and Functional Image in Asialoglycoprotein Receptor Scintigraphy: A Novel Modality for Evaluating the Regional Dynamic Function of Hepatocytes

Department of Surgery, Tokyo Metropolitan Kiyose Children’s Hospital, Kiyose, Tokyo, Japan

View larger version (26K): [in a new window]   FIGURE 1. Principle behind calculating mean transit time. TAC = time-activity curve.

View larger version (15K): [in a new window]   FIGURE 2. Correlation between MTT and clearance index.

View larger version (12K): [in a new window]   FIGURE 3. Correlation between MTT and receptor index.

View larger version (12K): [in a new window]   FIGURE 4. Patients were divided into 2 groups on basis of receptor index value. Mean MTT ± SD is indicated for each group.

View larger version (41K): [in a new window]   FIGURE 5. A 2-mo-old boy with high level of serum bile acid of unknown etiology: Serum bilirubin level was 1.2 mg/dL (range, 0.3–1.5 mg/dL), whereas alanine transaminase level was 43 IU/L (range, 13–33 IU/L) and aspartate transaminase level was 40 IU/L (range, 8–42 IU/L). (A) Original time–activity curve for whole liver (blue curve) and horizontal mirror image curve of time-activity curve (white curve). (B) Conventional 99mTc-GSA image. (C) Functional image obtained at same time as image in B.

View larger version (28K): [in a new window]   FIGURE 6. A 19-d-old boy with biliary atresia. Serum bilirubin level was 9.8 mg/dL, alanine transaminase level was 66 IU/L, and aspartate transaminase level was 30 IU/L. (A) Functional image at 19 d old shows exacerbated dynamic function of right hepatic lobe. Warm colors indicate good MTT and cold colors indicate poor MTT. (B) Functional image at 6 mo old and 5 mo after the Kasai operation. Serum bilirubin level was 6.3 mg/dL, alanine transaminase level was 372 IU/L, and aspartate transaminase level was 212 IU/L. (C) Functional image at 6 y old and 5 y after living-related partial liver transplantation. Hepatic functions were all within normal range.