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Comparison of 1-11C-Glucose and 18F-FDG for Quantifying Myocardial Glucose Use with PET

Pilar Herrero, MS1, Terry L. Sharp1, Carmen Dence, MS1, Brendan M. Haraden, MD2 and Robert J. Gropler, MD1,2

1 Cardiovascular Imaging Laboratory, Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri
2 Cardiovascular Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri



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  		FIGURE 1. Myocardial 18F-FDG and 1-11C-glucose short-axis images obtained 30–60 min after injection of tracer in dogs studied during either IL/R, HIC/R, or HIC/PHEN. Black is lowest activity and white is highest activity. A = anterior; I = inferior; L = lateral; LV = left ventricle; RV = right ventricle; S = septum.

 


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  		FIGURE 2. (A) Correlation between PET-derived measurements of myocardial uptake of 1-11C-glucose and direct measurements of myocardial uptake of 1-11C-glucose. (B) Correlation between PET-derived measurements of myocardial uptake of 18F-FDG and direct measurements of myocardial uptake of 18F-FDG. D = dobutamine.

 


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  		FIGURE 3. (A) Correlation between direct measurements of myocardial uptake of 1-11C-glucose and unlabeled glucose. (B–D) Correlation between direct measurements of myocardial uptake of 18F-FDG and unlabeled glucose for uncorrected 18F-FDG K values (B), values corrected by LC (C), and values corrected by LCv (D). D = dobutamine.

 


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  		FIGURE 4. Correlation between PET-derived (y-axis) and Fick-derived (x-axis) measurements of rMGU from 1-11C-glucose (A), from 18F-FDG before correcting PET values (B), from 18F-FDG after correcting PET values by LC (C), and from 18F-FDG after correcting PET values by LCv (D). D = dobutamine.

 




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