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Evaluation of Pediatric CNS Malignancies with ^99mTc-Methoxyisobutylisonitrile SPECT

¹ Department of Pediatrics, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada
² Department of Nuclear Medicine, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada
³ Department of Pediatric Oncology, Alberta Children’s Hospital, University of Calgary, Calgary, Alberta, Canada

View larger version (80K): [in a new window]   FIGURE 1. Glioblastoma multiforme of right frontotemporal region, revealed on T1-weighted MRI with gadolinium (A) and T2-weighted MRI (B), is also well defined on sestamibi scan (C).

View larger version (112K): [in a new window]   FIGURE 2. Serial pairings of sagittal MRI and SPECT images for 15-y-old boy with exophytic brain stem glioma. Third column is black-and-white version of original SPECT images. Baseline images (A) are compared with scans at 8 (B) and 12 (C) mo, both of which show increased signal on 99mTc-MIBI SPECT but no change on MRI. Final panel (D) demonstrates increased tumor on MRI at 16 mo, accompanied by decreased signal from SPECT.