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Spironolactone Improves Cardiac Sympathetic Nerve Activity and Symptoms in Patients with Congestive Heart Failure

¹ Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
² Kitakanto Cardiovascular Hospital, Gunma, Japan

View larger version (15K): [in a new window]   FIGURE 1. Cardiac 123I-MIBG uptake was quantified as H/M ratio 4 h after injection, using regions of interest positioned over heart (H) and upper mediastinum (M).

View larger version (15K): [in a new window]   FIGURE 2. Segmentation scheme used to quantitate regional 123I-MIBG uptake.

View larger version (67K): [in a new window]   FIGURE 3. Representative SPECT 123I-MIBG images before and after spironolactone treatment in dilated cardiomyopathy.

View larger version (97K): [in a new window]   FIGURE 4. Representative anterior planar 123I-MIBG images before and after spironolactone treatment in dilated cardiomyopathy. In this example, delayed H/M ratio increased from 1.90 to 2.46, and WR decreased from 49 to 33.

View larger version (20K): [in a new window]   FIGURE 5. Changes in NYHA functional class during treatment in the 2 groups. 6M = after 6 mo of therapy.