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Considerations of Marrow Cellularity in 3-Dimensional Dosimetric Models of the Trabecular Skeleton

¹ Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida
² Department of Physics and Astronomy, Francis Marion University, Florence, South Carolina
³ Center for Structural Biology, University of Florida Brain Institute, University of Florida, Gainesville, Florida

View larger version (128K): [in a new window]   FIGURE 1. Two-dimensional region of interest selected from 3D NMR image of trabecular bone sample sectioned from male femoral head. Four values of marrow cellularity are displayed: 10% (A), 50% (B), 80% (C), and 100% (D). Gray voxels represent simulated adipocyte cell clusters defining inactive marrow tissue.

View larger version (27K): [in a new window]   FIGURE 2. Electron absorbed fractions calculated for 10%, 30%, 50%, 80%, and 100% marrow cellularity using macrostructural transport model for femoral head of 51-y-old man. Values shown are average absorbed fractions of 2 separate bone samples sectioned from femoral head (<4% variation at high energies).

View larger version (25K): [in a new window]   FIGURE 3. Electron absorbed fractions calculated for 10%, 30%, 50%, 80%, and 100% marrow cellularity using macrostructural transport model for humeral epiphysis of 51-y-old man.

View larger version (27K): [in a new window]   FIGURE 4. Specific absorbed fractions for monoenergetic electrons calculated for 10%, 30%, 50%, 80%, and 100% marrow cellularity using macrostructural transport model for femoral head of 51-y-old man.

View larger version (25K): [in a new window]   FIGURE 5. Electron absorbed fractions for self-irradiation of TAM within femoral head of 51-y-old man. Three dosimetry methodologies are compared. Method of Bouchet et al. (27,28) assumes that TAM self-absorbed fractions are equal to TMS self-absorbed fractions, whereas method of Eckerman and Stabin (15) scales TMS self-absorbed fractions by reference cellularity factor (0.25 for femoral head). TAM self-absorbed fractions reported in this study are calculated directly using macrostructural transport model of EGS4 transport code (solid line, no data points). Dashed lines indicate potential variations in absorbed fraction with changes in individual marrow cellularity either lower than that of reference man (10%) or higher than that of reference man (40%).

View larger version (27K): [in a new window]   FIGURE 6. Electron-specific absorbed fractions for self-irradiation of TAM within femoral head of 51-y-old man. Values are obtained by dividing each curve in Figure 5 by corresponding mass of active marrow. Dashed lines indicate potential variations in specific absorbed fraction with changes in individual marrow cellularity either lower than that of reference man (10%) or higher than that of reference man (40%).