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Imaging of Ischemic but Viable Myocardium Using a New 18F-Labeled 2-Nitroimidazole Analog, 18F-FRP170

Tomohiro Kaneta, MD1, Yoshihiro Takai, MD, PhD1, Yutaka Kagaya, MD, PhD2, Yuriko Yamane, MD, PhD2, Hiroaki Wada, PhD3, Masahiro Yuki, PhD3, Ren Iwata, PhD3, Michihiko Tsujitani, PhD4, Shoki Takahashi, MD, PhD1 and Shogo Yamada, MD, PhD1

1 Department of Radiology, Tohoku University, Sendai, Japan
2 Department of Cardiovascular Medicine, Tohoku University, Sendai, Japan
3 Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan
4 POLA Chemical Industries, Yokohama, Japan



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  		FIGURE 1. Experimental protocols. (A) Protocol 1: 18F-FRP170 and 14C-IAP. (B) Protocol 2: 18F-FRP170 and 125I-BMIPP. (C) Protocol 3: 18F-FRP170 and 14C-DG. i.v. = intravenous injection.

 


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  		FIGURE 2. Representative double-tracer autoradiograms obtained from each protocol. All coupled autoradiograms were obtained from same slice. In each group, autoradiograms on left show 18F-FRP170 image. Autoradiograms on right show image with 14C-IAP as marker of myocardial perfusion (A), 125I-BMIPP as marker of myocardial fatty acid metabolism (B), and 14C-DG as marker of myocardial glucose metabolism in slice obtained from heart of nondiabetic rat (C) and slice obtained from heart of diabetic rat (D). Autoradiograms on right were expressed at same window level and width.

 


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  		FIGURE 3. Circumferential profile curves of 2 radiotracers used in protocols 1, 2, and 3. (A) 18F-FRP170 and 14C-IAP. (B) 18F-FRP170 and 125I-BMIPP. (C) 18F-FRP170 and 14C-DG. ROIs were placed in serial order in midmyocardial layer of left ventricular wall. Sept. = septum; Post. = posterior; Lat. = lateral; Ant. = anterior.

 


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  		FIGURE 4. Representative TTC-stained section of heart subjected to 30 min of LCA ligation followed by 24 h of reperfusion. Dark area represents nonischemic area stained with Evans blue. Viable myocardium in risk area (red) is located at periphery and necrotic myocardium (pale) is at center of risk area.

 




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