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Cardiac Adrenergic Innervation Is Affected in Asymptomatic Subjects with Very Early Stage of Coronary Artery Disease

Sakari Simula, MD1, Esko Vanninen, MD, PhD2, Laura Viitanen, MD1, Anu Kareinen, MD1, Seppo Lehto, MD, PhD1, Pia Pajunen, MD3, Mikko Syvänne, MD, PhD3, Jyrki Kuikka, PhD2, Markku Laakso, MD, PhD1 and Juha Hartikainen, MD, PhD1

1 Department of Medicine, Kuopio University Hospital, Kuopio, Finland
2 Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
3 Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland



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  		FIGURE 1. Schematic representation of myocardium divided into 8 segments. Segments 1–4 represent anteroseptal, 5–6 lateral, and 7–8 inferior myocardium. Black areas indicate myocardial regions excluded from analysis (apex in center and most basal layer on border).

 


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  		FIGURE 2. Correlation between LAD stenosis and myocardial MIBI uptake at rest and during exercise, MIBG uptake, and MIBG washout of anteroseptal myocardial region. ns = not statistically significant; nu = normalized units; rest = rest imaging.

 


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  		FIGURE 3. Delayed regional myocardial MIBG uptake (A) and regional myocardial MIBG washout (B) divided into tertiles according to stenoses of respective coronary artery. I = lowest tertile; II = middle tertile; III = highest tertile; nu = normalized unit. *P < 0.05. **P < 0.01. ***P < 0.001.

 




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