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Pharmacokinetics of [¹⁸F]FETNIM: A Potential Hypoxia Marker for PET

Medicity Research Laboratory and Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, Turku; and Department of Oncology and Radiotherapy, Turku University Central Hospital, Turku, Finland

View larger version (7K): [in a new window]   FIGURE 1. Radiochemical synthesis of [18F]FETNIM from 1-(2'-nitro-1'-imidazolyl)-2,3-O-isopropylidene-4-tosyloxybutane.

View larger version (13K): [in a new window]   FIGURE 2. Typical chromatograms of rat and human tissues as detected by radio-TLC and digital autoradiography. Human plasma sample was analyzed at 30 min after injection of [18F]FETNIM, whereas rat tumor and liver samples were analyzed at 60 min. Radiochromatograms of rat and human plasma were qualitatively and quantitatively similar. arb. = arbitrary.

View larger version (13K): [in a new window]   FIGURE 3. Relationship between percentage of unchanged [18F]FETNIM and uptake in DMBA-induced rat tumors. Poor correlation was observed at early times (A and B), but, at later time, significant inverse correlation was found (C).