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Assessment of Residual Coronary Stenoses Using ^99mTc-N-NOET Vasodilator Stress Imaging to Evaluate Coronary Flow Reserve Early After Coronary Reperfusion in a Canine Model of Subendocardial Infarction

Experimental Cardiology Laboratory, Cardiovascular Division, Department of Medicine, University of Virginia, Charlottesville, Virginia

View larger version (16K): [in a new window]   FIGURE 1. Experimental protocol. mic = radiolabeled microspheres.

View larger version (25K): [in a new window]   FIGURE 2. Comparison of mean LAD/LCx defect count ratio obtained from background-subtracted in vivo images. Transmural myocardial blood flow ratio at time when 99mTc-N-NOET was administered during vasodilator stress is superimposed for comparison. Note that initial and 60-min delayed defect count ratios were significantly less in group 2 dogs with residual stenoses than those in group 1 dogs with no stenoses, reflecting greater diminution in coronary flow reserve preserved in group 2 dogs. *P < 0.05 vs. injection flow ratio; P < 0.01 vs. group 1; P < 0.05 vs. initial image.

View larger version (25K): [in a new window]   FIGURE 3. Comparison of mean LAD/LCx defect count ratio obtained from ex vivo images and mean LAD/LCx activity count ratio obtained from -well counting. For comparison, transmural blood flow ratio is superimposed. LAD/LCx ratios of ex vivo defect and -well activity count were less in group 2 dogs than those in group 1 dogs, revealing diminished coronary flow reserve during vasodilator stress in group 2 dogs with critical stenoses. *P < 0.05 vs. injection flow ratio; P < 0.01 vs. group 1.