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Evaluation of Limited Blood Sampling in a Preceding 99mTc-Labeled Diagnostic Study to Predict the Pharmacokinetics and Myelotoxicity of 186Re-cMAb U36 Radioimmunotherapy

David R. Colnot, Abraham J. Wilhelm, Jacqueline Cloos, Jan C. Roos, Remco de Bree, Jasper J. Quak, Gordon B. Snow and Guus A.M.S. van Dongen

Departments of Otolaryngology/Head and Neck Surgery and Nuclear Medicine, Vrije Universiteit Medical Center, Amsterdam, The Netherlands



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  		FIGURE 1. Relationship between red marrow absorbed dose estimates and development of thrombocytopenia after 186Re-cMAb U36 radioimmunotherapy. Red marrow absorbed dose estimate was calculated using Bayesian analysis of limited blood sampling at 4 and 72 h after administration of 186Re-cMAb U36.

 




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