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Molecular Biologic and Scintigraphic Analyses of Somatostatin Receptor-Negative Meningiomas

Department of Dermatology, University of Cologne, Cologne; Department of Nuclear Medicine, University Hospital Eppendorf, Hamburg; and Department of Anatomy and Clinic of Nuclear Medicine, Christian-Albrechts-University, Kiel, Germany

View larger version (102K): [in a new window]   FIGURE 1. Coronal gadolinium-DTPA–enhanced T1-weighted MRI slices of SRS OP4 meningioma (A) and SRS ON4 meningioma (B).

View larger version (52K): [in a new window]   FIGURE 2. SRS and 99mTc-DTPA scintigraphy of SRS OP4 meningioma. (A) Planar somatostatin receptor scintigram 4 h after injection of 200 MBq 111In-octreotide in anterior and posterior projection. R = right; L = left; V = ventral; D = dorsal. (B) Corresponding transverse SPECT slice at 4 h. (C) Transverse SPECT slice 1 h after injection of 600 MBq 99mTc-DTPA.

View larger version (73K): [in a new window]   FIGURE 3. SRS and 99mTc-DTPA scintigraphy of SRS ON4 meningioma. (A) Planar somatostatin receptor scintigram 4 h after injection of 200 MBq 111In-octreotide in anterior and posterior projection. R = right; L = left; V = ventral; D = dorsal. (B) Corresponding transverse SPECT slice at 4 h. (C) Transverse SPECT slice 1 h after injection of 600 MBq 99mTc-DTPA.

View larger version (59K): [in a new window]   FIGURE 4. Ethidium bromide–stained agarose electrophoresis gel after separating RT-PCR amplificates with primers of hsst2 (377 bp) and hß-actin (650 bp) from 4 SRS OP1–OP4 meningiomas (top) and 4 SRS ON1–ON4 meningiomas (bottom). Control reactions were performed by omitting RNA. Sizes (bp) of marker fragments are indicated (left lane, top; left and right lanes, bottom).

View larger version (129K): [in a new window]   FIGURE 5. Immunocytochemical visualization of somatostatin receptor subtype 2 on surface of OP4 (A) and ON4 (B) cultivated cells. Control reactions were performed by preincubating primary antibody with surplus of its antigenic peptide, OP4 (C) or ON4 (D). (x170)