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Evaluation of Early-Stage Parkinson’s Disease with 99mTc-TRODAT-1 Imaging

Wen-Sheng Huang, Shinn-Zong Lin, Jiann-Chyun Lin, Shiaw-Pyng Wey, Gann Ting and Ren-Shyan Liu

Departments of Nuclear Medicine, Neurological Surgery, and Neurology, National Defense Medical Center, Tri-Service General Hospital, Taipei; Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei; and Institute of Nuclear Energy Research, Lung-Tan, Taiwan, Republic of China



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FIGURE 1. 99mTc-TRODAT-1 SPECT in transverse views of healthy volunteer (A) and of patients with HYS stage I (B) and stage II (C) Parkinson’s disease. Asymmetric striatal uptake was observed, with more profound loss contralateral to symptoms or more affected limbs.

 


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FIGURE 2. Specific striatal uptake of 99mTc-TRODAT-1 in healthy volunteers and in patients with HYS stage I and stage II Parkinson’s disease.

 


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FIGURE 3. Specific putaminal uptake of 99mTc-TRODAT-1 in healthy volunteers and in patients with HYS stage I and stage II Parkinson’s disease.

 


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FIGURE 4. Specific putaminal uptake of 99mTc-TRODAT-1 in healthy volunteers and in patients with HYS stage I Parkinson’s disease contralateral and ipsilateral to symptoms.

 


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FIGURE 5. Specific putaminal uptake of 99mTc-TRODAT-1 in healthy volunteers and in patients with HYS stage II Parkinson’s disease contralateral and ipsilateral to symptoms.

 


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FIGURE 6. Specific posterior putaminal uptake of 99mTc-TRODAT-1 in healthy volunteers and in patients with HYS stage I Parkinson’s disease ipsilateral to symptoms.

 





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