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^99mTc-Interleukin-8 for Imaging Acute Osteomyelitis

Department of Nuclear Medicine and Section of Histomorphology, Orthopaedic Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands

View larger version (218K): [in a new window]   FIGURE 1. (A) Medullar tissue of control animal containing numerous fat cells (v) and red marrow (x150). (B) Medullar tissue of low-grade infection: fibrous tissue and osteoclastic erosion on endosteal surface of femoral cortex (x150). (C) Large accumulation of PMNs in medullar tissue of heavily infected bone specimen (x50). (D) Enlargement of central part because of PMN accumulation (x250). (E) Erosion channels and osteoclasts (arrows) in cortical infected bone (x100). (F) Eroded areas in cortical bone filled with leukocytes (x80).

View larger version (9K): [in a new window]   FIGURE 2. In vivo measurements of granulocyte function. Graph shows lung clearance of 111In-granulocytes determined by quantitative analysis of scintigraphic images of rabbits that received 111In-granulocytes. Error bars represent SEM.

View larger version (93K): [in a new window]   FIGURE 3. Scintigraphic images of rabbits with complete infection of femur. (Top) 99mTc-IL-8 image 4 h after injection (left) and 67Ga-citrate image 48 h after injection (right) for rabbit 8 of group B. (Bottom) 99mTc-MDP image 4 h after injection (left) and 111In-granulocyte image 48 h after injection (right) for rabbit 1 of group A.

View larger version (12K): [in a new window]   FIGURE 4. Uptake at osteomyelitic site as determined by quantitative analysis of scintigraphic images of group A rabbits administered 99mTc-MDP and 111In-granulocytes and group B rabbits administered 99mTc-IL-8 and 67Ga-citrate. Error bars represent SEM.

View larger version (9K): [in a new window]   FIGURE 5. T/Bs calculated from quantitative region-of-interest analysis of scintigraphic images. Data are for 3-h (99mTc-MDP) and 48-h (111In-granulocyte) images for rabbits of group A and for 4-h (99mTc-IL-8) and 48-h (67Ga-citrate) images for rabbits of group B. Horizontal bars represent mean values.