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Effect of Whole-Body 18F-FDG PET Imaging on Clinical Staging and Management of Patients with Malignant Lymphoma

Heiko Schöder, Joubin Meta, Cecilia Yap, Maryam Ariannejad, Jyotsna Rao, Michael E. Phelps, Peter E. Valk, Jim Sayre and Johannes Czernin

Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic/Nuclear Medicine, University of California, Los Angeles, School of Medicine, Los Angeles; and Northern California PET Imaging Center, Sacramento, California



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FIGURE 1. (A) A 70-y-old male patient who presented initially with NHL of right neck. PET was performed for staging and revealed additional involvement of left cervical and mediastinal lymph nodes as well as right lung (arrows). This finding resulted in upstaging from stage I to stage II and change in treatment from irradiation to medical treatment. (B) A 27-y-old female patient with HD. After treatment with chemotherapy, she had cervical recurrence 2 y later. Repeated chemotherapy resulted in remission. Five months later, CT scan revealed multiple equivocal 8- to 10-mm lymph nodes in right axilla. PET revealed right axillary lymphadenopathy, right supra- and infraclavicular and left infraclavicular nodes (arrows), and retroperitoneal and pelvic involvement. As result of PET, patient underwent salvage chemotherapy followed by allogenic bone marrow transplantation.

 





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