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PET Imaging of Somatostatin Receptors Using [⁶⁸GA]DOTA-D-Phe¹-Tyr³-Octreotide: First Results in Patients with Meningiomas

Department of Nuclear Medicine, University of Heidelberg, Heidelberg; German Cancer Research Center, Heidelberg, Germany; University Hospital Basel, Basel, Switzerland; and Medical School Hannover, Hannover, Germany

View larger version (23K): [in a new window]   FIGURE 1. (A) Mean SUV for meningiomas, pituitary glands, and healthy brain tissue, 0–120 min after injection of 175 MBq [68Ga]DOTATOC. (B) Contrast ratio of meningiomas to healthy brain tissue, 0–120 min after injection. (C) Coronal, transaxial, and sagittal PET scans of two intraventricular (arrowheads) and one parietal meningioma (arrow). Stereotactic localizer system surrounding skull. (D) Physiologic SSTR expression of pituitary gland (arrowheads) and meninges (arrows). Stereotactic localizer-system surrounding skull.

View larger version (54K): [in a new window]   FIGURE 2. (A) Realigned CT, PET, and MRI scans of medial temporal/sphenoidal meningioma (arrow) beneath pituitary gland (arrowhead). (B) Image fusion of same patient (color coded, PET; black and white, MRI).