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On the Quantification of [¹⁸F]MPPF Binding to 5-HT_1A Receptors in the Human Brain

PET Center, Groningen University Hospital, Groningen; Groningen University Institute for Drug Exploration, Groningen, The Netherlands

View larger version (21K): [in a new window]   FIGURE 1. Time–activity (Act) curves (A) and corresponding specific binding (B) for several regions in 1 volunteer after administration of 79 MBq [18F]MPPF.

View larger version (32K): [in a new window]   FIGURE 2. Comparison of BPs obtained by Logan analysis (21) using metabolite-corrected arterial input (BP LP metab. corr.) with uncorrected arterial input (BP LP uncorr.) (A), with cerebellar input (BP LP cereb. input) (B), with simplified reference tissue method (BP ref. tis. [cereb.] (27)) (C), and with compartmental modeling (BP 3-comp. model) (D).

View larger version (36K): [in a new window]   FIGURE 3. Comparison of frame summation (5–60 min) (A) with results of pixel-by-pixel–based parametric imaging of Logan analysis using metabolite-corrected arterial input (B), cerebellar input (C) (21), and simplified reference tissue method (D) (27) at level of basal ganglia (BG) and medial temporal cortex (MTC).