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Comparison of Cardiac Sympathetic Nervous Function with Left Ventricular Function and Perfusion in Cardiomyopathies by 123I-MIBG SPECT and 99mTc-Tetrofosmin Electrocardiographically Gated SPECT

Chunlei Zhao, Noriyuki Shuke, Wakako Yamamoto, Atsutaka Okizaki, Junichi Sato, Yukio Ishikawa, Takahumi Ohta, Naoyuki Hasebe, Kenjiro Kikuchi and Tamio Aburano

Department of Radiology and First Department of Internal Medicine, Asahikawa Medical College; and Section of Radiology, Asahikawa Medical College Hospital, Asahikawa, Japan



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  		FIGURE 1. Diagram of myocardial segments of left ventricle on short-axial plane. IS = inferior septal; AS = anterior septal; ANT = anterior; AL = anterior lateral; IL = inferior lateral; INF = inferior.

 


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  		FIGURE 2. Examples of 99mTc-tetrofosmin and 131I-MIBG SPECT. Short-axial images of 55-y-old healthy man (A), 59-y-old man with DCM (B), and 15-y-old boy with HCM (C). In DCM and HCM, myocardial MIBG uptake was significantly decreased on delayed images.

 


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  		FIGURE 3. Group means of regional parameters. n = number of myocardial segments; UPes = tetrofosmin uptake at end-systole; MUPe = early MIBG uptake; MUPd = delayed MIBG uptake.

 


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  		FIGURE 4. Correlation between regional MIBG washout and wall thickening in DCM and HCM. n = number of myocardial segments.

 


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  		FIGURE 5. Correlation between regional early MIBG uptakes and perfusion in DCM and HCM. n = number of myocardial segments.

 




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