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Positron Emission Mammography–Guided Breast Biopsy

Center for Advanced Imaging, Department of Radiology, West Virginia University, Morgantown, West Virginia; and Detector Group, Jefferson Laboratory, Newport News, Virginia

View larger version (92K): [in a new window]   FIGURE 1. Stereotactic software user interface. Display windows show ±15° images of breast phantom. User marks center of fiducial marker with x and center of lesion with +.

View larger version (110K): [in a new window]   FIGURE 2. Gelatin compressed-breast phantom containing 10-mm-diameter simulated lesion.

View larger version (118K): [in a new window]   FIGURE 3. Experimental setup. Most notable sections of apparatus have been labeled: gelatin breast phantom (A), anthropomorphic torso phantom (B), 500-mL beaker simulating bladder (C), 20-cm-diameter flood phantom simulating brain (D), 2 PEM detector units (E), x-ray tube of breast biopsy apparatus (Lorad, Danbury, CT) (F), biopsy needle positioning unit (G), biopsy gun (H), and proximal compression plate (I).

View larger version (19K): [in a new window]   FIGURE 4. Plots of calculated versus known positions of 18F point sources show results for x-coordinate (A), y-coordinate (B), and z-coordinate (C). Fits of each set of data to straight line are also shown.

View larger version (22K): [in a new window]   FIGURE 5. Images of gelatin breast phantom. (A) X-ray mammogram of phantom acquired at 0°. (B) PEM image of phantom acquired at 0°. Dashed box delineates outline of field of view of x-ray mammography unit. Ramp filter window function with cutoff value of 14% of Nyquist frequency was applied to image. Object in lower portion of PEM image is fiducial marker. Size scales of x-ray mammogram and PEM image are same to show differences in field of view of the 2 imagers.

View larger version (10K): [in a new window]   FIGURE 6. Image of biopsy needle tip (blue color scale) overlaid with filtered PEM image of breast phantom (red color scale) used to assess needle positioning before firing of biopsy gun. Ramp filter window function with cutoff value of 14% of Nyquist frequency was applied to image. Image was acquired at detector rotation angle of -15°.