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Rapid Imaging of Experimental Colitis with ^99mTc-Interleukin-8 in Rabbits

Department of Nuclear Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands

View larger version (39K): [in a new window]   FIGURE 1. Scintigraphic images of rabbits with experimental colitis, imaged at 2 min and at 1, 2, and 4 h after injection, together with separate image of dissected colon of 99mTc-HMPAO-granulocytes (A). In vivo, no nonspecific bowel uptake is seen until 4 h after injection and 99mTc-HYNIC-IL-8 (B).

View larger version (19K): [in a new window]   FIGURE 2. CIs of both radiotracers at 1 h (A) and 4 h (B) postinjection (p.i.) compared with severity of macroscopic inflammation (grade 0 = normal; grade1 = inflammation; grade 2 = ulceration). Error bars represent SEM.

View larger version (125K): [in a new window]   FIGURE 3. Macroscopic aspect of colonic mucosa in TNBS-induced acute colitis. Scoring of inflammation is shown: 0 = normal (colon descending); 1 = inflammation (sigmoid colon); 2 = ulceration (rectum).