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Prediction of Myocardial Infarction Versus Cardiac Death by Gated Myocardial Perfusion SPECT: Risk Stratification by the Amount of Stress-Induced Ischemia and the Poststress Ejection Fraction

Division of Nuclear Medicine, Department of Imaging, and Division of Cardiology, Department of Medicine, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles; and Department of Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, California

View larger version (18K): [in a new window]   FIGURE 1. Univariate (A and B) and multivariate (C) Cox regression analysis for prediction of CD and nonfatal MI. LK = prescan likelihood of coronary disease; DM = diabetes mellitus. *P < 0.02. **P < 0.001.

View larger version (13K): [in a new window]   FIGURE 2. Annual CD rate as function of EF. Number of patients at each 10% interval is indicated in parentheses.

View larger version (13K): [in a new window]   FIGURE 3. Cumulative survival with stratification by EF. Number of patients in each subgroup is indicated.

View larger version (11K): [in a new window]   FIGURE 4. Nonfatal MI rate as function of SDS. Number of patients at each 5-unit interval is indicated.

View larger version (13K): [in a new window]   FIGURE 5. Cumulative hazard of nonfatal MI with stratification by presence or absence of ischemia. Number of patients in each subgroup is indicated.

View larger version (19K): [in a new window]   FIGURE 6. CD rate as function of amount of ischemia in patients with EF >50% and EF between 30% and 50% (A) and in patients with EF <30% (B). Mod = moderate. *P < 0.05 vs. EF >50% in same perfusion category. **P < 0.005 compared with no ischemia and same EF category.

View larger version (24K): [in a new window]   FIGURE 7. Risk stratification by poststress EF and amount of stress-induced ischemia.