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Quantification of Regional Myocardial Blood Flow Using Dynamic H215O PET and Factor Analysis

Ji Young Ahn, Dong Soo Lee, Jae Sung Lee, Seok-Ki Kim, Gi Jeong Cheon, Jeong Seok Yeo, Seung-Ai Shin, June-Key Chung and Myung Chul Lee

Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul; Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul; and Department of Physics, Ewha Womans University, Seoul, Korea



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  		FIGURE 1. Schematic representation of processing steps of factor analysis to yield input function and regional myocardial TACs. LV = left ventricle; RV = right ventricle.

 


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  		FIGURE 2. Right ventricular (RV) (A), left ventricular (LV) (B), and myocardial (C) factor images obtained from first step of factor analysis. All dynamic H215O PET studies gave consistent results.

 


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  		FIGURE 3. Input functions by factor analysis and arterial sampling. Blood samples were drawn from radial arteries.

 


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  		FIGURE 4. Representative TACs of left ventricle and myocardium. Curves were obtained by factor analysis (A) and ROI method (B).

 


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  		FIGURE 5. Correlations between rMBF by factor analysis and rMBF by microsphere studies (r = 0.95; y = 0.95x + 0.26) (A) and between rMBF by ROI method and rMBF by microsphere studies (r = 0.93; y = 0.88x - 0.01) (B).

 




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