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An Introduction to PET and SPECT Neuroreceptor Quantification Models*

Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland; PET Imaging Center, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; and Biomedical Imaging Research Center, Fukui Medical University, Fukui, Japan

View larger version (12K): [in a new window]   FIGURE 1. In vitro system consists of two compartments. Terms are defined in Appendix.

View larger version (27K): [in a new window]   FIGURE 2. Two- and three-compartment configurations used to model in vivo radioligand kinetics. Terms are defined in Appendix.

View larger version (114K): [in a new window]   FIGURE 3. Selected [123I]IBF dopamine D2 receptor images of healthy individual (left) and patient with multiple-system atrophy (right). Paired central activity reflects striatal dopamine D2 binding, which is markedly reduced in patient. (Reprinted with permission of (30).)

View larger version (15K): [in a new window]   FIGURE 4. Plasma (A) and brain ROI (B) time–activity curves from [123I]IBF SPECT study of healthy individual. (Reprinted with permission of (30).)