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Receptor Measurements via Tc-GSA Kinetic Modeling Are Proportional to Functional Hepatocellular Mass

Kenji Miki, Keiichi Kubota, Yusuke Inoue, David R. Vera and Masatoshi Makuuchi

Departments of Hepato-Biliary-Pancreatic Surgery and Radiology, Faculty of Medicine, University of Tokyo, Tokyo, Japan; and Department of Radiology, University of California, San Diego, La Jolla, California



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  		FIGURE 1. Kinetic model of Tc-GSA with receptor endocytosis and recycling. Using this model, total receptor amount (Rtotal) was measured by computer-automated analysis of Tc-GSA liver and heart time–activity curves.

 


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  		FIGURE 2. Rtotal and total number of viable hepatocytes within subject’s liver exhibited high correlation. {circ} = normal; {triangleup} = chronic hepatitis; {lozenge} = cirrhosis.

 




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