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Absolute Changes in Regional Cerebral Blood Flow in Association with Upright Posture in Humans: An Orthostatic PET Study

Yasuomi Ouchi, Hiroyuki Okada, Etsuji Yoshikawa, Masami Futatsubashi and Shuji Nobezawa

Positron Medical Center, Hamamatsu Medical Center, Hamakita; Central Research Laboratory, Hamamatsu Photonics K.K., Hamakita, Japan



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  		FIGURE 1. ROI setting. Irregular ROIs, drawn on concerned regions of MR images (A), were placed on corresponding PET images (B) superimposed on MR images. Ce = cerebellum; I Fro = inferior frontal; Occ = occipital cortex; Par = parietal; S Fro = superior frontal; Str = striatum; Tha = thalamus; V = vermis.

 


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  		FIGURE 2. Correlations between age and rCBF in different postures in cerebellum (supine, r = 0.13; sitting, r = 0.26; standing, r = 0.43) and upper frontal area (supine, r = 0.25; sitting, r = 0.23; standing, r = 0.55). Absolute levels of upper frontal rCBF in standing position tended to decrease with age. CBF = cerebral blood flow; {circ} with dashed line = supine; {blacktriangleup} with dotted line = sitting; {diamondsuit} with solid line = standing.

 


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  		FIGURE 3. (A) Standing position versus supine position. Significant increase in relative rCBF is detected in anterior vermis and visual cortex. (B) Standing position versus sitting position. Significant increase in rCBF is still detected in anterior vermis. Details of coordinates and z values are given in Table 3.

 




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