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MIRD Pamphlet No. 18: Administered Cumulated Activity for Ventilation Studies

Stephen R. Thomas, MIRD Committee: E.E. Watson (Chair), W.E. Bolch, A.B. Brill, N.D. Charkes, D.R. Fisher, M.T. Hays, R.W. Howell, R.F. Meredith, J.S. Robertson, G. Sgourous, J.A. Siegel, S.R. Thomas, B.W. Wessels

Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio



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  		FIGURE 1. Schematic representation of radioisotope inhalation delivery systems. (A) Rebreathing system. (B) Continuous-flow generator output system. (C) Radioaerosol delivery system. Terms are defined in text.

 


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  		FIGURE 2. Activity in lung space, AL(t), as function of time. At time ta, administration phase is concluded and washout begins. Activity equilibrium distribution (AL)E is established for rebreathing and generator systems; however, for radioaerosol delivery system, administration is terminated on rising portion of lung activity curve.

 


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  		FIGURE 3. Example of rebreathing ventilation protocol shows lung administered cumulated activity per initial spirometer activity as function of wash-in half-time for ta = 5 min.

 


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  		FIGURE 4. Example of generator ventilation technique shows lung administered cumulated activity per generator activity output rate as function of wash-in half-time.

 


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  		FIGURE 5. Example of radioaerosol ventilation technique shows lung administered cumulated activity per initial nebulizer activity as function of wash-in half-time.

 




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