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Use of ^99mTc-Labeled Liposomes Encapsulating Blue Dye for Identification of the Sentinel Lymph Node

Department of Radiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas

View larger version (91K): [in a new window]   FIGURE 1. Blue-biotin-liposomes. Liposomes remained intense blue color even after three centrifugation washes before resuspension.

View larger version (29K): [in a new window]   FIGURE 2. Scintigrams show anterior views of legs and lower abdomen of rabbit at 0 min (baseline), 30 min, 60 min, and 24 h after subcutaneous injection of 99mTc-labeled blue-biotin-liposomes in both hind feet; this was followed by subcutaneous injection of avidin in only left hind foot. Increased retention of 99mTc activity in left popliteal node compared with right popliteal node is easily visualized at 60 min and 24 h.

View larger version (82K): [in a new window]   FIGURE 3. (A) Posterior aspect of hind legs of rabbit show exposed popliteal nodes at necropsy at 24 h. Feet of rabbit are located superior to picture. Blue coloration of popliteal node on experimental side (right side of image) that received avidin is readily observed. (B) Excised experimental (right side of image) and control (left side of image) popliteal nodes.