HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) CME Activity Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jager, P. L. Articles by Piers, D. A. Search for Related Content PubMed PubMed Citation Articles by Jager, P. L. Articles by Piers, D. A.

Radiolabeled Amino Acids: Basic Aspects and Clinical Applications in Oncology*

Department of Nuclear Medicine, PET Center, and Department of Medical Oncology, University Hospital Groningen, Groningen, The Netherlands; and Institute of Medicine, Research Center Jülich, Jülich, Germany

View larger version (99K): [in a new window]   FIGURE 1. Anterior (left) and posterior (right) whole-body IMT scintigrams of healthy volunteer 30 min after injection show low-grade brain, liver, and spleen uptake and intense kidney and urinary system uptake.

View larger version (124K): [in a new window]   FIGURE 2. Maximum-intensity projection from TYR PET study shows normal distribution in chest and upper abdomen; low uptake in bone marrow, liver, and stomach; and intense uptake in pancreas.

View larger version (157K): [in a new window]   FIGURE 3. Planar IMT image obtained 1 wk after 60 Gy radiotherapy in patient with non–small cell lung carcinoma in right middle lobe shows nonspecific increased uptake in irradiated field (arrows).

View larger version (98K): [in a new window]   FIGURE 4. Coronal, transverse, and sagittal images obtained using H215O (perfusion, left column), FDG (middle column), and TYR (right column) in patient with large, low-grade astrocytoma in left temporoparietal region show that tumor is not intensely perfused and glucose metabolism is low. However, large area of irregularly increased amino acid uptake is clearly seen, and amino acid uptake is noted in lacrimal gland.

View larger version (40K): [in a new window]   FIGURE 5. IMT SPECT (top row) and MET PET (bottom row) images of brain of patient with glioma show similar uptake and tumor delineation. Resolution of MET PET was converted to SPECT resolution.

View larger version (60K): [in a new window]   FIGURE 6. Coronal and sagittal projections of TYR PET study of patient with large, recurrent squamous cell carcinoma of right maxillary sinus extending into skull base show irregularly increased TYR uptake in tumor (thick arrows). Because of irradiation, uptake in both parotid glands and right submandibular gland has disappeared, and uptake in left submandibular gland is visible (thin arrows).

View larger version (172K): [in a new window]   FIGURE 7. Coronal chest IMT SPECT section through 6-cm squamous cell carcinoma in right middle lobe of same patient as in Figure 3 shows high IMT uptake.

View larger version (112K): [in a new window]   FIGURE 8. Transverse chest IMT SPECT image of patient with large cell carcinoma of left upper lobe and mediastinal metastasis shows avid uptake in both.

View larger version (58K): [in a new window]   FIGURE 9. Coronal IMT SPECT sections through upper legs of patient with high-grade malignant fibrous histiocytoma, before (left) and after (right) regional hyperthermic cytostatic perfusion of leg, show disappearance of irregular intense IMT uptake after perfusion, in agreement with complete tumor necrosis.