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Neuroblastoma Imaging Using a Combined CT Scanner–Scintillation Camera and ¹³¹I-MIBG

Departments of Radiology and Pediatrics, University of California, San Francisco, California

View larger version (12K): [in a new window]   FIGURE 1. Combined CT–scintillation camera imaging system.

View larger version (69K): [in a new window]   FIGURE 2. Overview of template projection reconstruction process.

View larger version (59K): [in a new window]   FIGURE 3. Example of fused image available from combined CT–scintillation camera imaging system. CT image is shown along with spatially correlated SPECT image indicating 131I-MIBG uptake in lymph node in patient’s left axilla.

View larger version (92K): [in a new window]   FIGURE 4. Anterior planar 131I-MIBG scans of three neuroblastoma patients. Patient 1 shows two separate lesions in abdomen along with normal liver uptake (left side of image) and excreted bladder activity (lower portion of image). Patient 2 shows one lesion in left clavicle and one near left axilla along with liver uptake (lower portion of image) and diffuse low-level background tissue uptake. Patient 3 shows two (faint) lesions in abdomen along with normal liver uptake (left side of image) and intense activity in large bowel.

View larger version (116K): [in a new window]   FIGURE 5. Coregistered CT and reconstructed SPECT images of patient 1.

View larger version (103K): [in a new window]   FIGURE 6. Coregistered CT and reconstructed SPECT images of patient 2.

View larger version (101K): [in a new window]   FIGURE 7. Coregistered CT and reconstructed SPECT images of patient 3. In images on right, central focus is small lesion that does not appear to anatomically correspond to left adrenal; left focus is part of large lesion; and right focus is part of bowel uptake.