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A Comparison in Monkeys of 99mTc Labeled to a Peptide by 4 Methods

Mary Rusckowski, Tong Qu, Suresh Gupta, Arthur Ley and Donald J. Hnatowich

Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester; and Dyax Corporation, Cambridge, Massachusetts



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  		FIGURE 1. Clearance from plasma of 99mTc labeled to HNE-2 using MAG3 (•), MAS3 ({blacklozenge}), DTPA ({blacksquare}), and HYNIC ({blacktriangleup}).

 


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  		FIGURE 2. Size-exclusion HPLC radiochromatograms of 99mTc labeled to HNE-2 using 4 chelators in saline (A) and in plasma collected from monkeys at 5 min (B), 13–30 min (C), and 60 min (D).

 


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  		FIGURE 3. Radioactivity clearance in liver (%ID) over 4 h for HNE-2 labeled using MAG3 (•), MAS3 ({blacklozenge}), DTPA ({blacksquare}), and HYNIC ({blacktriangleup}). Data points represent averages (n = 2 or 3) for each chelator.

 


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  		FIGURE 4. Radioactivity clearance in kidneys (%ID) over 4 h for HNE-2 labeled using MAG3 (•), MAS3 ({blacklozenge}), DTPA ({blacksquare}), and HYNIC ({blacktriangleup}). Data points represent averages (n = 2 or 3) for each chelator.

 


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  		FIGURE 5. Radioactivity ratios between lesion (%ID) to plasma (%ID/mL) over 4 h for HNE-2 labeled using MAG3 (•), MAS3 ({blacklozenge}), DTPA ({blacksquare}), and HYNIC ({blacktriangleup}).

 


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  		FIGURE 6. Logarithm–logarithm correlation plot of %ID per organ in monkey and mouse in kidney (K), liver (L), heart (H), and spleen (S). Data are taken from Table 1.

 


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  		FIGURE 7. Composite of scintigraphic images in monkeys 3 h after administration, with 1 example shown for each of 4 99mTc-chelate complexes.

 




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